Quantum Chemical Structure Activity Studies of Anticancer Activity of Seconucleoside Nitrosourea Analogs
نویسندگان
چکیده
منابع مشابه
A QUANTUM CHEMICAL STUDY OF STRUCTURE -ACTIVITY RELATIONSHIPS OF DIHYDROPYRIDINE CALCIUM ANTAGONISTS
Quantum chemical (MNDo)caleulations have beenused toelucidate the molecular properties and structure - activity relationships of dihydropyridine (DHP) type calcium antagonists. There is a good corielation between the net atomic charges on various atoms of the 4 - phenyl ring of dihydropyridines and pharmacological activity. .Also, activity decreases with increasing free rotation of the phen...
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This discussion of structure-activity relationships is confined to two or the more important classes of anticancer agentswthe alkylating agents and the antimetaboliteswand to results obtained with these compounds in experimental animal therapy. An attempt is made to point to correlations between the anticancer activity and the structure of these compounds. From these structure-activity correlat...
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ژورنال
عنوان ژورنال: Chemical Informatics
سال: 2016
ISSN: 2470-6973
DOI: 10.21767/2470-6973.100015